Neonatal outcome in patients with rheumatic disease
Identifieur interne : 001F76 ( Main/Exploration ); précédent : 001F75; suivant : 001F77Neonatal outcome in patients with rheumatic disease
Auteurs : M. Motta [Italie] ; A. Tincani [Italie] ; A. Lojacono [Italie] ; D. Faden [Italie] ; R. Gorla [Italie] ; P. Air [Italie] ; F. Neri [Italie] ; A. Gasparoni [Italie] ; L. Ciardelli [Italie] ; A. De Silvestri [Italie] ; M. Marconi [Italie] ; G. Chirico [Italie]Source :
- Lupus [ 0961-2033 ] ; 2004-09.
English descriptors
- Teeft :
- American academy, Antiphospholipid, Antiphospholipid antibodies, Antiphospholipid syndrome, Arthritis rheum, Autoantibody, Autoimmune, Autoimmune disease, Birth weight, Breastfeeding, Breastfeeding infant, Care unit, Case reports, Coll cardiol, Congenital, Congenital heart block, Connective tissue diseases, Fetal, Fetus, Growth restriction, Health care providers, Heart block, Hepatobiliary disease, Idiopathic thrombocytopenic purpura, Immune, Immune function, Immune system, Immune thrombocytopenic purpura, Immunosuppressant treatment, Immunosuppressive, Immunosuppressive agents, Immunosuppressive drugs, Intracranial hemorrhage, Lupus, Lupus erythematosus, Lymphocyte subpopulations, Maternal, Maternal autoantibodies, Maternal disease, Maternal medication, Medication, Motta, National registry, Neonatal, Neonatal lupus, Neonatal lupus erythematosus, Neonatal outcome, Neonatal thrombocytopenia, Obstet gynecol, Obstetrical complications, Paps pregnancy, Pediatrics, Platelet, Platelet count, Platelet counts, Pregnancy, Pregnant women, Preterm, Preterm delivery, Prospective study, Purpura, Rheum, Rheumatic, Rheumatic disease, Spedali civili, Syndrome, Tetani toxoid, Tetani toxoid vaccination, Third trimester, Thrombocytopenia, Thrombocytopenic.
Abstract
Rheumatic autoimmune diseases have a higher prevalence in women, particularly during their childbearing age. Due to improved management, an increasing number of patients plan and carry out one or more pregnancies. Therefore, a growing interest is being paid to the possible consequences of maternal disease and associated treatment on the fetus and newborn infant. If maternal disease is characterized by the presence of IgG isotype autoantibodies, these can cross the placenta with possible antibody-mediated damage to the fetus. This is typically the case of the so called neonatal lupus erythematosus (NLE); a similar mechanism has been shown in infants of patients with immune thrombocytopenic purpura (ITP) and, less frequently, in those from mothers with antiphospholipid syndrome (APS). Indeed, this last condition is often responsible for placental, rather than neonatal, pathology. In addition, immunosuppressive and other drugs administered to the mothers during pregnancy and lactation might affect the fetal and neonatal immune system development. Finally, mothers disease and/or treatment could be related to neuropsychological alteration reported in some of their children.
Url:
DOI: 10.1191/0961203403lu2002oa
Affiliations:
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Due to improved management, an increasing number of patients plan and carry out one or more pregnancies. Therefore, a growing interest is being paid to the possible consequences of maternal disease and associated treatment on the fetus and newborn infant. If maternal disease is characterized by the presence of IgG isotype autoantibodies, these can cross the placenta with possible antibody-mediated damage to the fetus. This is typically the case of the so called neonatal lupus erythematosus (NLE); a similar mechanism has been shown in infants of patients with immune thrombocytopenic purpura (ITP) and, less frequently, in those from mothers with antiphospholipid syndrome (APS). Indeed, this last condition is often responsible for placental, rather than neonatal, pathology. In addition, immunosuppressive and other drugs administered to the mothers during pregnancy and lactation might affect the fetal and neonatal immune system development. Finally, mothers disease and/or treatment could be related to neuropsychological alteration reported in some of their children.</div></front></TEI><affiliations><list><country><li>Italie</li></country></list><tree><country name="Italie"><noRegion><name sortKey="Motta, M" sort="Motta, M" uniqKey="Motta M" first="M" last="Motta">M. Motta</name></noRegion><name sortKey="Air, P" sort="Air, P" uniqKey="Air P" first="P" last="Air">P. Air</name><name sortKey="Chirico, G" sort="Chirico, G" uniqKey="Chirico G" first="G" last="Chirico">G. Chirico</name><name sortKey="Ciardelli, L" sort="Ciardelli, L" uniqKey="Ciardelli L" first="L" last="Ciardelli">L. Ciardelli</name><name sortKey="De Silvestri, A" sort="De Silvestri, A" uniqKey="De Silvestri A" first="A" last="De Silvestri">A. De Silvestri</name><name sortKey="Faden, D" sort="Faden, D" uniqKey="Faden D" first="D" last="Faden">D. Faden</name><name sortKey="Gasparoni, A" sort="Gasparoni, A" uniqKey="Gasparoni A" first="A" last="Gasparoni">A. Gasparoni</name><name sortKey="Gorla, R" sort="Gorla, R" uniqKey="Gorla R" first="R" last="Gorla">R. Gorla</name><name sortKey="Lojacono, A" sort="Lojacono, A" uniqKey="Lojacono A" first="A" last="Lojacono">A. Lojacono</name><name sortKey="Marconi, M" sort="Marconi, M" uniqKey="Marconi M" first="M" last="Marconi">M. Marconi</name><name sortKey="Neri, F" sort="Neri, F" uniqKey="Neri F" first="F" last="Neri">F. Neri</name><name sortKey="Tincani, A" sort="Tincani, A" uniqKey="Tincani A" first="A" last="Tincani">A. Tincani</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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